Tissue Regeneration

Bone regeneration

Genis has shown that chitosan has osteoinductive properties, stimulating healthy bone tissue formation, for example at fractures sites and across vertebrae.

These findings have resulted in the development of a novel bone graft substitute that has been shown to have superior bone tissue regenerative properties in in vivo experiments compared with common bone graft substitutes.

The injectable bone graft substitute BoneReg-InjectTM was found to have strong osteogenic and osteoconductive properties in experiments performed in sheep tibia, without any foreing body reaction. Over time, the substitute is resorbed with stimulated formation of continuous bone formation that replaces the substitute material, with minimal fibrous tissue formation.

Spinal fusion using Genis‘ proprietary
BoneReg osteoinductive material

3D printed tissue scaffolds

Genis has developed a three dimensional (3D) bioactive scaffold that promotes healthy tissue formation, leveraging our understanding of the tissue regenerative properties of chitin derivatives. Using 3D printing techniques, intricate scaffolds of any desired geometric configuration can be generated with high resolution to promote tissue regeneration, for example to replace/augment bone regeneration at site of fracture or other bone deficiency.

The combination of the high resolution that 3D printing provides, together with the unique regenerative properties of our proprietary chitosan compositions, we will be able to provide a platform of bioactive scaffolds that combine healthy tissue formation and mechanical strength that can be used to replace damaged or missing bone tissue.

Bioactive implants

Our tissue regeneration program also includes novel implants that are treated with our proprietary chitosan material. Through a research program sponsored in part by a grant from the European Union, Genis has developed a method of coating titanium implants with our chitosan composition. Using this novel method and our chitosan material, we can deliver bioactive material to the surface of the implants, thereby modulating the host response to the implants through the promotion of healthy tissue formation around the site of implant.