A system of chitinases and chitinase-like proteins (the CLP system) plays an important role in humans, being involved in the regulation of:
- Wound healing
In healthy adults, activity of the CLP system is stable and highly regulated. However, during the development of dysregulated inflammation, CLP expression increases significantly.
Prolonged and excessive activation of the CLP system can create a destructive environment that can ultimately lead to disease.
A number of previous studies have shown that targeting the CLP system is likely to provide a clinically meaningful response, including studies in asthma, rheumatoid arthritis and in cancer.